Ontology highlight
ABSTRACT:
SUBMITTER: Paiva CN
PROVIDER: S-EPMC3386808 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Paiva Claudia N CN Feijó Daniel F DF Dutra Fabianno F FF Carneiro Vitor C VC Freitas Guilherme B GB Alves Letícia S LS Mesquita Jacilene J Fortes Guilherme B GB Figueiredo Rodrigo T RT Souza Heitor S P HS Fantappié Marcelo R MR Lannes-Vieira Joseli J Bozza Marcelo T MT
The Journal of clinical investigation 20120625 7
Oxidative damage contributes to microbe elimination during macrophage respiratory burst. Nuclear factor, erythroid-derived 2, like 2 (NRF2) orchestrates antioxidant defenses, including the expression of heme-oxygenase-1 (HO-1). Unexpectedly, the activation of NRF2 and HO-1 reduces infection by a number of pathogens, although the mechanism responsible for this effect is largely unknown. We studied Trypanosoma cruzi infection in mice in which NRF2/HO-1 was induced with cobalt protoporphyrin (CoPP) ...[more]