Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins.
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ABSTRACT:
SUBMITTER: Takamatsu D
PROVIDER: S-EPMC1418684 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
Binding of the streptococcal surface glycoproteins GspB and Hsa to human salivary proteins.
Takamatsu Daisuke D Bensing Barbara A BA Prakobphol Akraporn A Fisher Susan J SJ Sullam Paul M PM
Infection and immunity 20060301 3
GspB and Hsa are homologous surface glycoproteins of Streptococcus gordonii that bind sialic acid moieties on platelet membrane glycoprotein Ibalpha. Since this species is an important member of the oral flora, we examined the direct binding of these adhesins to human salivary proteins. Both GspB and Hsa bound low-molecular-weight salivary mucin MG2 and salivary agglutinin. Hsa also bound several other salivary proteins, including secretory immunoglobulin A. Screening of six oral streptococcal i ...[more]
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