MyD88 innate immune function in a zebrafish embryo infection model.
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ABSTRACT:
SUBMITTER: van der Sar AM
PROVIDER: S-EPMC1418923 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Publications
MyD88 innate immune function in a zebrafish embryo infection model.
van der Sar Astrid M AM Stockhammer Oliver W OW van der Laan Carina C Spaink Herman P HP Bitter Wilbert W Meijer Annemarie H AH
Infection and immunity 20060401 4
Innate immunity signaling mechanisms during vertebrate embryogenesis are largely unknown. To study Toll-like receptor (TLR) signaling function in the zebrafish embryo model, we designed an experimental setup for antisense morpholino knockdown under conditions of bacterial infection. Clearance of Salmonella enterica serovar Typhimurium Ra bacteria was significantly impaired after knockdown of myeloid differentiation factor 88 (MyD88), a common adaptor protein in TLR and interleukin-1 receptor sig ...[more]
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