Ontology highlight
ABSTRACT:
SUBMITTER: van der Sar AM
PROVIDER: S-EPMC1418923 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Infection and immunity 20060401 4
Innate immunity signaling mechanisms during vertebrate embryogenesis are largely unknown. To study Toll-like receptor (TLR) signaling function in the zebrafish embryo model, we designed an experimental setup for antisense morpholino knockdown under conditions of bacterial infection. Clearance of Salmonella enterica serovar Typhimurium Ra bacteria was significantly impaired after knockdown of myeloid differentiation factor 88 (MyD88), a common adaptor protein in TLR and interleukin-1 receptor sig ...[more]