Ontology highlight
ABSTRACT:
SUBMITTER: Kaboudin B
PROVIDER: S-EPMC1421414 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Beilstein journal of organic chemistry 20060316
Reactions of O,O'-dialkyl thiophosphoric acids with alkyl halides, in the presence of a base, provide a direct synthetic route to phosphorothioates via O,O'-dialkyl thiophosphate anion formation. Studies on the reaction of ambident nucleophile ammonium O,O'-diethyl thiophosphate with benzyl halides and tosylate in different solvents show that only S-alkylation is obtained. Reaction of this ambident nucleophile with benzoyl chloride (a hard electrophile), gave the O-acylation product. A simple, e ...[more]