In vitro development of resistance to human immunodeficiency virus protease inhibitor GW640385.
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ABSTRACT:
SUBMITTER: Yates PJ
PROVIDER: S-EPMC1426426 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
In vitro development of resistance to human immunodeficiency virus protease inhibitor GW640385.
Yates P J PJ Hazen R R St Clair M M Boone L L Tisdale M M Elston R C RC
Antimicrobial agents and chemotherapy 20060301 3
Development of in vitro resistance to GW640385, a new human immunodeficiency virus type 1 protease inhibitor, was studied. Variants characterized included one with <4-fold resistance and amino acid substitutions Q58E/A71V (protease) and P452K (Gag) and one with >50-fold resistance and amino acid substitutions L10F/G16E/E21K/A28S/M46I/F53L/A71V (protease) and L449F/P453T (Gag). The A28S substitution substantially reduced replication capacity. ...[more]
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