Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance.
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SUBMITTER: Johnston E
PROVIDER: S-EPMC529213 | biostudies-literature | 2004 Dec
REPOSITORIES: biostudies-literature
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Association of a novel human immunodeficiency virus type 1 protease substrate cleft mutation, L23I, with protease inhibitor therapy and in vitro drug resistance.
Johnston Elizabeth E Winters Mark A MA Rhee Soo-Yon SY Merigan Thomas C TC Schiffer Celia A CA Shafer Robert W RW
Antimicrobial agents and chemotherapy 20041201 12
We observed a previously uncharacterized mutation in the protease substrate cleft, L23I, in 31 of 4,303 persons undergoing human immunodeficiency virus type 1 genotypic resistance testing. In combination with V82I, L23I was associated with a sevenfold reduction in nelfinavir susceptibility and a decrease in replication capacity. In combination with other drug resistance mutations, L23I was associated with multidrug resistance and a compensatory increase in replication capacity. ...[more]
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