Ontology highlight
ABSTRACT:
SUBMITTER: Sourisseau T
PROVIDER: S-EPMC1430269 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Sourisseau Tony T Georgiadis Anastasios A Tsapara Anna A Ali Robin R RR Pestell Richard R Matter Karl K Balda Maria S MS
Molecular and cellular biology 20060301 6
The tight junction protein ZO-1 inhibits G1/S-phase transition by cytoplasmic sequestration of a complex formed by CDK4 and the transcription factor ZONAB. Canine ZONAB is the homologue of human DbpA, an E2F target gene that is overexpressed in different carcinomas. Since the ZONAB target genes that are involved in G1/S-phase transition are unknown, we employed the mammary epithelial cell line MCF-10A and cDNA arrays to screen for such genes. We identified genes encoding cell cycle and replicati ...[more]