Ontology highlight
ABSTRACT:
SUBMITTER: Barrantes Idel B
PROVIDER: S-EPMC1430294 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Molecular and cellular biology 20060301 6
dickkopf (dkk) genes encode a small family of secreted Wnt antagonists, except for dkk3, which is divergent and whose function is poorly understood. Here, we describe the generation and characterization of dkk3 mutant mice. dkk3-deficient mice are viable and fertile. Phenotypic analysis shows no major alterations in organ morphology, physiology, and most clinical chemistry parameters. Since Dkk3 was proposed to function as thyroid hormone binding protein, we have analyzed deiodinase activities, ...[more]