Ontology highlight
ABSTRACT:
SUBMITTER: Conway AJ
PROVIDER: S-EPMC6093728 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Conway Ashlee J AJ Brown Fiona C FC Rank Gerhard G Kile Benjamin T BT Morton Craig J CJ Jane Stephen M SM Curtis David J DJ
Blood advances 20180801 15
To identify novel regulators of erythropoiesis, we performed independent forward genetic screens using the chemical mutagen ENU in mice. Among progeny displaying microcytic red-cell phenotypes, 7 independent mouse strains harboring mutations within the transferrin receptor gene <i>Tfrc</i> were identified. Six of the mutants, including the previously described red blood cell 6 (RBC6) strain, displayed reduced erythroblast CD71 expression and midgestation lethality of homozygotes (E12.5-E14.5), a ...[more]