Ontology highlight
ABSTRACT:
SUBMITTER: O'Donnell KA
PROVIDER: S-EPMC1430295 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
O'Donnell Kathryn A KA Yu Duonan D Zeller Karen I KI Kim Jung-Whan JW Racke Frederick F Thomas-Tikhonenko Andrei A Dang Chi V CV
Molecular and cellular biology 20060301 6
Overexpression of transferrin receptor 1 (TFRC1), a major mediator of iron uptake in mammalian cells, is a common feature of human malignancies. Therapeutic strategies designed to interfere with tumor iron metabolism have targeted TFRC1. The c-Myc oncogenic transcription factor stimulates proliferation and growth by activating thousands of target genes. Here we demonstrate that TFRC1 is a critical downstream target of c-Myc. Using in vitro and in vivo models of B-cell lymphoma, we show that TFRC ...[more]