Proteins pattern alteration in AZT-treated K562 cells detected by two-dimensional gel electrophoresis and peptide mass fingerprinting.
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ABSTRACT:
SUBMITTER: D'Andrea G
PROVIDER: S-EPMC1435870 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
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Proteins pattern alteration in AZT-treated K562 cells detected by two-dimensional gel electrophoresis and peptide mass fingerprinting.
D'Andrea Gabriele G Lizzi Anna R AR Venditti Sara S Di Francesco Laura L Giorgi Alessandra A Mignogna Giuseppina G Oratore Arduino A Bozzi Argante A
Proteome science 20060329
In this study we report the effect of AZT on the whole protein expression profile both in the control and the AZT-treated K562 cells, evidenced by two-dimensional gel electrophoresis and peptide mass fingerprinting analysis. Two-dimensional gels computer digital image analysis showed two spots that appeared up-regulated in AZT-treated cells and one spot present only in the drug exposed samples. Upon extraction and analysis by peptide mass fingerprinting, the first two spots were identified as PD ...[more]
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