Ontology highlight
ABSTRACT:
SUBMITTER: Roignant JY
PROVIDER: S-EPMC1447592 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Roignant Jean-Yves JY Hamel Sophie S Janody Florence F Treisman Jessica E JE
Genes & development 20060401 7
Activation of the Raf kinase by GTP-bound Ras is a poorly understood step in receptor tyrosine kinase signaling pathways. One such pathway, the epidermal growth factor receptor (EGFR) pathway, is critical for cell differentiation, survival, and cell cycle regulation in many systems, including the Drosophila eye. We have identified a mutation in a novel gene, aveugle, based on its requirement for normal photoreceptor differentiation. The phenotypes of aveugle mutant cells in the eye and wing imag ...[more]