Ontology highlight
ABSTRACT:
SUBMITTER: Duca M
PROVIDER: S-EPMC1447649 | biostudies-literature | 2006
REPOSITORIES: biostudies-literature
Duca Maria M Guianvarc'h Dominique D Oussedik Kahina K Halby Ludovic L Garbesi Anna A Dauzonne Daniel D Monneret Claude C Osheroff Neil N Giovannangeli Carine C Arimondo Paola B PB
Nucleic acids research 20060405 6
Human topoisomerase II (topo II) is the cellular target for a number of widely used antitumor agents, such as etoposide (VP16). These agents 'poison' the enzyme and induce it to generate DNA breaks that are lethal to the cell. Topo II-targeted drugs show a limited sequence preference, triggering double-stranded breaks throughout the genome. Circumstantial evidence strongly suggests that some of these breaks induce chromosomal translocations that lead to specific types of leukaemia (called treatm ...[more]