Ontology highlight
ABSTRACT:
SUBMITTER: Walisko O
PROVIDER: S-EPMC1449646 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Walisko Oliver O Izsvák Zsuzsanna Z Szabó Kornélia K Kaufman Christopher D CD Herold Steffi S Ivics Zoltán Z
Proceedings of the National Academy of Sciences of the United States of America 20060307 11
We used the Sleeping Beauty (SB) transposable element as a tool to probe transposon-host cell interactions in vertebrates. The Miz-1 transcription factor was identified as an interactor of the SB transposase in a yeast two-hybrid screen. Through its association with Miz-1, the SB transposase down-regulates cyclin D1 expression in human cells, as evidenced by differential gene expression analysis using microarray hybridization. Down-regulation of cyclin D1 results in a prolonged G(1) phase of the ...[more]