The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells.
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ABSTRACT:
SUBMITTER: Taylor MR
PROVIDER: S-EPMC1449739 | biostudies-literature | 2005 May
REPOSITORIES: biostudies-literature
Publications
The zebrafish pob gene encodes a novel protein required for survival of red cone photoreceptor cells.
Taylor Michael R MR Kikkawa Satoshi S Diez-Juan Antonio A Ramamurthy Visvanathan V Kawakami Koichi K Carmeliet Peter P Brockerhoff Susan E SE
Genetics 20050216 1
The zebrafish mutant, partial optokinetic response b (pob), was isolated using an N-ethyl N-nitrosourea (ENU)-based screening strategy designed to identify larvae with defective optokinetic responses in red but not white light. Previous studies showed that red-light blindness in pob is due to the specific loss of long-wavelength photoreceptor cells via an apoptotic mechanism. Here, we used positional cloning to identify the mutated pob gene. We find that pob encodes a highly conserved 30-kDa pro ...[more]
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