Brakeless is required for photoreceptor growth-cone targeting in Drosophila.
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ABSTRACT:
SUBMITTER: Rao Y
PROVIDER: S-EPMC18542 | biostudies-literature | 2000 May
REPOSITORIES: biostudies-literature
Publications
brakeless is required for photoreceptor growth-cone targeting in Drosophila.
Rao Y Y Pang P P Ruan W W Gunning D D Zipursky S L SL
Proceedings of the National Academy of Sciences of the United States of America 20000501 11
The R1-R6 subclass of photoreceptor neurons (R cells) in the Drosophila compound eye form specific connections with targets in the optic ganglia. In this paper, we report the identification of a gene, brakeless (bks), that is essential for R1-R6 growth cone targeting. In brakeless mutants, R1-R6 growth cones frequently fail to terminate migration in their normal target, the lamina, and instead project through it and terminate in the second optic ganglion, the medulla. Genetic mosaic analysis and ...[more]
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