Ontology highlight
ABSTRACT:
SUBMITTER: Yasuhiko Y
PROVIDER: S-EPMC1450137 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Yasuhiko Yukuto Y Haraguchi Seiki S Kitajima Satoshi S Takahashi Yu Y Kanno Jun J Saga Yumiko Y
Proceedings of the National Academy of Sciences of the United States of America 20060227 10
Mesp2 is a transcription factor that plays fundamental roles in somitogenesis, and its expression is strictly restricted to the anterior presomitic mesoderm just before segment border formation. The transcriptional on-off cycle is linked to the segmentation clock. In our current study, we show that a T-box transcription factor, Tbx6, is essential for Mesp2 expression. Tbx6 directly binds to the Mesp2 gene upstream region and mediates Notch signaling, and subsequent Mesp2 transcription, in the an ...[more]