Ontology highlight
ABSTRACT:
SUBMITTER: Sadahiro T
PROVIDER: S-EPMC6190602 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Sadahiro Taketaro T Isomi Mari M Muraoka Naoto N Kojima Hidenori H Haginiwa Sho S Kurotsu Shota S Tamura Fumiya F Tani Hidenori H Tohyama Shugo S Fujita Jun J Miyoshi Hiroyuki H Kawamura Yoshifumi Y Goshima Naoki N Iwasaki Yuka W YW Murano Kensaku K Saito Kuniaki K Oda Mayumi M Andersen Peter P Kwon Chulan C Uosaki Hideki H Nishizono Hirofumi H Fukuda Keiichi K Ieda Masaki M
Cell stem cell 20180809 3
The mesoderm arises from pluripotent epiblasts and differentiates into multiple lineages; however, the underlying molecular mechanisms are unclear. Tbx6 is enriched in the paraxial mesoderm and is implicated in somite formation, but its function in other mesoderms remains elusive. Here, using direct reprogramming-based screening, single-cell RNA-seq in mouse embryos, and directed cardiac differentiation in pluripotent stem cells (PSCs), we demonstrated that Tbx6 induces nascent mesoderm from PSC ...[more]