Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.
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ABSTRACT:
SUBMITTER: Koike H
PROVIDER: S-EPMC1450143 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Publications
Disc1 is mutated in the 129S6/SvEv strain and modulates working memory in mice.
Koike Hiroko H Arguello P Alexander PA Kvajo Mirna M Karayiorgou Maria M Gogos Joseph A JA
Proceedings of the National Academy of Sciences of the United States of America 20060216 10
Disrupted-In-Schizophrenia (DISC1) is a leading candidate schizophrenia susceptibility gene. Here, we describe a deletion variant in mDisc1 specific to the 129S6/SvEv strain that introduces a termination codon at exon 7, abolishes production of the full-length protein, and impairs working memory performance when transferred to the C57BL/6J genetic background. Our findings provide insights into how DISC1 variation contributes to schizophrenia susceptibility in humans and the behavioral divergence ...[more]
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