Ontology highlight
ABSTRACT:
SUBMITTER: Pickford AR
PROVIDER: S-EPMC145459 | biostudies-literature | 2001 Apr
REPOSITORIES: biostudies-literature
Pickford A R AR Smith S P SP Staunton D D Boyd J J Campbell I D ID
The EMBO journal 20010401 7
The solution structure of the (6)F1(1)F2(2)F2 fragment from the gelatin-binding region of fibronectin has been determined (Protein Data Bank entry codes 1e88 and 1e8b). The structure reveals an extensive hydrophobic interface between the non-contiguous (6)F1 and (2)F2 modules. The buried surface area between (6)F1 and (2)F2 ( approximately 870 A(2)) is the largest intermodule interface seen in fibronectin to date. The dissection of (6)F1(1)F2(2)F2 into the (6)F1(1)F2 pair and (2)F2 results in ne ...[more]