Ontology highlight
ABSTRACT:
SUBMITTER: Plun-Favreau H
PROVIDER: S-EPMC145510 | biostudies-literature | 2001 Apr
REPOSITORIES: biostudies-literature
Plun-Favreau H H Elson G G Chabbert M M Froger J J deLapeyrière O O Lelièvre E E Guillet C C Hermann J J Gauchat J F JF Gascan H H Chevalier S S
The EMBO journal 20010401 7
Ciliary neurotrophic factor (CNTF) is involved in the survival of a number of different neural cell types, including motor neurons. CNTF functional responses are mediated through a tripartite membrane receptor composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor (LIFR), associated with a non-signalling CNTF binding receptor alpha component (CNTFR). CNTFR-deficient mice show profound neuronal deficits at birth, leading to a lethal phenotype. In contrast, ...[more]