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A novel chimeric gene, siren, with retroposed promoter sequence in the Drosophila bipectinata complex.

ABSTRACT: Retrotransposons often produce a copy of host genes by their reverse transcriptase activity operating on host gene transcripts. Since transcripts normally do not contain promoter, a retroposed gene copy usually becomes a retropseudogene. However, in Drosophila bipectinata and a closely related species we found a new chimeric gene, whose promoter was likely produced by retroposition. This chimeric gene, named siren, consists of a tandem duplicate of Adh and a retroposed fragment of CG11779 containing the promoter and a partial intron in addition to the first exon. We found that this unusual structure of a retroposed fragment was obtained by retroposition of nanos, which overlaps with CG11779 on the complementary strand. The potential of retroposition to produce a copy of promoter and intron sequences in the context of gene overlapping was demonstrated.

SUBMITTER: Nozawa M

PROVIDER: S-EPMC1456098 | biostudies-literature | 2005 Dec

REPOSITORIES: biostudies-literature

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A novel chimeric gene, siren, with retroposed promoter sequence in the Drosophila bipectinata complex.

Nozawa Masafumi M Aotsuka Tadashi T Tamura Koichiro K

Genetics 20050902 4

Retrotransposons often produce a copy of host genes by their reverse transcriptase activity operating on host gene transcripts. Since transcripts normally do not contain promoter, a retroposed gene copy usually becomes a retropseudogene. However, in Drosophila bipectinata and a closely related species we found a new chimeric gene, whose promoter was likely produced by retroposition. This chimeric gene, named siren, consists of a tandem duplicate of Adh and a retroposed fragment of CG11779 contai ...[more]

PMID: 16143626

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