Ontology highlight
ABSTRACT:
SUBMITTER: Toshima JY
PROVIDER: S-EPMC1458652 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Toshima Junko Y JY Toshima Jiro J Kaksonen Marko M Martin Adam C AC King David S DS Drubin David G DG
Proceedings of the National Academy of Sciences of the United States of America 20060330 15
Much progress defining the order and timing of endocytic internalization events has come as a result of real-time, live-cell fluorescence microscopy. Although the availability of numerous endocytic mutants makes yeast an especially valuable organism for functional analysis of endocytic dynamics, a serious limitation has been the lack of a fluorescent cargo for receptor-mediated endocytosis. We have now synthesized biologically active fluorescent mating-pheromone derivatives and demonstrated that ...[more]