Ontology highlight
ABSTRACT:
SUBMITTER: Monsonego A
PROVIDER: S-EPMC1458792 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Monsonego Alon A Imitola Jaime J Petrovic Sanja S Zota Victor V Nemirovsky Anna A Baron Rona R Fisher Yair Y Owens Trevor T Weiner Howard L HL
Proceedings of the National Academy of Sciences of the United States of America 20060320 13
Vaccination against amyloid beta-peptide (Abeta) has been shown to be successful in reducing Abeta burden and neurotoxicity in mouse models of Alzheimer's disease (AD). However, although Abeta immunization did not show T cell infiltrates in the brain of these mice, an Abeta vaccination trial resulted in meningoencephalitis in 6% of patients with AD. Here, we explore the characteristics and specificity of Abeta-induced, T cell-mediated encephalitis in a mouse model of the disease. We demonstrate ...[more]