Ontology highlight
ABSTRACT:
SUBMITTER: Eldor R
PROVIDER: S-EPMC1458796 | biostudies-literature | 2006 Mar
REPOSITORIES: biostudies-literature
Eldor R R Yeffet A A Baum K K Doviner V V Amar D D Ben-Neriah Y Y Christofori G G Peled A A Carel J C JC Boitard C C Klein T T Serup P P Eizirik D L DL Melloul D D
Proceedings of the National Academy of Sciences of the United States of America 20060321 13
Type 1 diabetes is characterized by the infiltration of inflammatory cells into pancreatic islets of Langerhans, followed by the selective and progressive destruction of insulin-secreting beta cells. Islet-infiltrating leukocytes secrete cytokines such as IL-1beta and IFN-gamma, which contribute to beta cell death. In vitro evidence suggests that cytokine-induced activation of the transcription factor NF-kappaB is an important component of the signal triggering beta cell apoptosis. To study the ...[more]