Ontology highlight
ABSTRACT:
SUBMITTER: Recht J
PROVIDER: S-EPMC1459006 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Recht J J Tsubota T T Tanny J C JC Diaz R L RL Berger J M JM Zhang X X Garcia B A BA Shabanowitz J J Burlingame A L AL Hunt D F DF Kaufman P D PD Allis C D CD
Proceedings of the National Academy of Sciences of the United States of America 20060420 18
Histone acetylation affects many nuclear processes including transcription, chromatin assembly, and DNA damage repair. Acetylation of histone H3 lysine 56 (H3 K56ac) in budding yeast occurs during mitotic S phase and persists during DNA damage repair. Here, we show that H3 K56ac is also present during premeiotic S phase and is conserved in fission yeast. Furthermore, the H3 K56ac modification is not observed in the absence of the histone chaperone Asf1. asf1delta and H3 K56R mutants exhibit simi ...[more]