Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC2597342 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Li Qing Q Zhou Hui H Wurtele Hugo H Davies Brian B Horazdovsky Bruce B Verreault Alain A Zhang Zhiguo Z
Cell 20080701 2
Chromatin assembly factor 1 (CAF-1) and Rtt106 participate in the deposition of newly synthesized histones onto replicating DNA to form nucleosomes. This process is critical for the maintenance of genome stability and inheritance of functionally specialized chromatin structures in proliferating cells. However, the molecular functions of the acetylation of newly synthesized histones in this DNA replication-coupled nucleosome assembly pathway remain enigmatic. Here we show that histone H3 acetylat ...[more]