Ontology highlight
ABSTRACT:
SUBMITTER: Kuramoto T
PROVIDER: S-EPMC14626 | biostudies-literature | 2001 Jan
REPOSITORIES: biostudies-literature
Kuramoto T T Kitada K K Inui T T Sasaki Y Y Ito K K Hase T T Kawagachi S S Ogawa Y Y Nakao K K Barsh G S GS Nagao M M Ushijima T T Serikawa T T
Proceedings of the National Academy of Sciences of the United States of America 20010101 2
The rat zitter (zi) mutation induces hypomyelination and vacuolation in the central nervous system (CNS), which result in early-onset tremor and progressive flaccid paresis. By positional cloning, we found a marked decrease in Attractin (Atrn) mRNA in the brain of the zi/zi rat and identified zi as an 8-bp deletion at a splice donor site of Atrn. Atrn has been known to play multiple roles in regulating physiological processes that are involved in monocyte-T cell interaction, agouti-related hair ...[more]