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Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.

ABSTRACT: Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and antiangiogenic agent is explored in the present study. tubA shows potent antiproliferative activity in a panel of human cancer cell lines irrespective of their multidrug resistance properties. It induces apoptosis in cancer cells but not in normal cells and shows significant potential antiangiogenic properties in several in vitro assays. It is efficacious in initial animal studies using a hollow fibre assay with 12 different human tumour cell lines. This study suggests that both in vitro and preclinical profiles of tubA may translate into clinically useful anticancer properties.

SUBMITTER: Kaur G

PROVIDER: S-EPMC1462728 | biostudies-literature | 2006 Jun

REPOSITORIES: biostudies-literature

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Biological evaluation of tubulysin A: a potential anticancer and antiangiogenic natural product.

Kaur Gurmeet G Hollingshead Melinda M Holbeck Susan S Schauer-Vukasinović Vesna V Camalier Richard F RF Dömling Alexander A Agarwal Seema S

The Biochemical journal 20060601 2

Tubulysin A (tubA) is a natural product isolated from a strain of myxobacteria that has been shown to depolymerize microtubules and induce mitotic arrest. The potential of tubA as an anticancer and antiangiogenic agent is explored in the present study. tubA shows potent antiproliferative activity in a panel of human cancer cell lines irrespective of their multidrug resistance properties. It induces apoptosis in cancer cells but not in normal cells and shows significant potential antiangiogenic p ...[more]

PMID: 16489930

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