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Total synthesis of psoralidin, an anticancer natural product.

ABSTRACT: A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner.

SUBMITTER: Pahari P

PROVIDER: S-EPMC2662043 | biostudies-literature | 2009 Apr

REPOSITORIES: biostudies-literature

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Total synthesis of psoralidin, an anticancer natural product.

Pahari Pallab P Rohr Jürgen J

The Journal of organic chemistry 20090401 7

A base-catalyzed condensation of phenyl acetate with acid chloride, followed by intramolecular cyclization and microwave-assisted cross-metathesis reaction, leads to the first total synthesis of psoralidin, a natural product with a broad range of biological activities, in a highly convergent and regioselective manner. ...[more]

PMID: 19254011

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