Ontology highlight
ABSTRACT:
SUBMITTER: Elenitoba-Johnson KS
PROVIDER: S-EPMC1464352 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Elenitoba-Johnson Kojo S J KS Crockett David K DK Schumacher Jonathan A JA Jenson Stephen D SD Coffin Cheryl M CM Rockwood Alan L AL Lim Megan S MS
Proceedings of the National Academy of Sciences of the United States of America 20060501 19
The anaplastic lymphoma kinase (ALK) on 2p23 is a tyrosine kinase that forms chimeric fusions with numerous translocation partners. We describe a mass spectrometry-based approach for the identification of ALK fusion partners. This approach accurately identified the nucleophosmin (NPM)-ALK fusion protein in an anaplastic large cell lymphoma (ALCL)-derived cell line carrying the t(2;5)(p23;q35), and the TPM3-ALK in a clinical biopsy of inflammatory myofibroblastic tumor (IMT) carrying the t(1;2)(q ...[more]