Ontology highlight
ABSTRACT:
SUBMITTER: Meinke G
PROVIDER: S-EPMC1472039 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Meinke Gretchen G Bullock Peter A PA Bohm Andrew A
Journal of virology 20060501 9
The origins of replication of DNA tumor viruses have a highly conserved feature, namely, multiple binding sites for their respective initiator proteins arranged as inverted repeats. In the 1.45-angstroms crystal structure of the simian virus 40 large T-antigen (T-ag) origin-binding domain (obd) reported herein, T-ag obd monomers form a left-handed spiral with an inner channel of 30 angstroms having six monomers per turn. The inner surface of the spiral is positively charged and includes residues ...[more]