Ontology highlight
ABSTRACT:
SUBMITTER: Meinke G
PROVIDER: S-EPMC3571380 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Meinke Gretchen G Phelan Paul J PJ Harrison Celia J CJ Bullock Peter A PA
Journal of virology 20121226 5
Polyomavirus origins of replication contain multiple occurrences of G(A/G)GGC, the high-affinity binding element for the viral initiator T-antigen (T-ag). The site I regulatory region of simian virus 40, involved in the repression of transcription and the enhancement of DNA replication initiation, contains two GAGGC sequences arranged head to tail and separated by a 7-bp AT-rich sequence. We have solved a 3.2-Å costructure of the SV40 origin-binding domain (OBD) bound to site I. We have also est ...[more]