Ontology highlight
ABSTRACT:
SUBMITTER: Zheng W
PROVIDER: S-EPMC1472502 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Zheng Wenjun W Brooks Bernard R BR Thirumalai D D
Proceedings of the National Academy of Sciences of the United States of America 20060508 20
By representing the high-resolution crystal structures of a number of enzymes using the elastic network model, it has been shown that only a few low-frequency normal modes are needed to describe the large-scale domain movements that are triggered by ligand binding. Here we explore a link between the nearly invariant nature of the modes that describe functional dynamics at the mesoscopic level and the large evolutionary sequence variations at the residue level. By using a structural perturbation ...[more]