Ontology highlight
ABSTRACT:
SUBMITTER: Zheng W
PROVIDER: S-EPMC3610319 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Current protein & peptide science 20090401 2
Allostery forms the basis of intra-molecular communications in various enzymes, however the underlying conformational changes are largely elusive. Recently, we have proposed to employ an elastic model based normal mode analysis to investigate the allosteric transitions in several molecular nanomachines (including myosin II, DNA polymerase and chaperonin GroEL). After combining with bioinformatics analysis of the evolutionary sequence variations, we have been able to identify the highly conserved ...[more]