Variants in the GH-IGF axis confer susceptibility to lung cancer.
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ABSTRACT:
SUBMITTER: Rudd MF
PROVIDER: S-EPMC1473180 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
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Variants in the GH-IGF axis confer susceptibility to lung cancer.
Rudd Matthew F MF Webb Emily L EL Matakidou Athena A Sellick Gabrielle S GS Williams Richard D RD Bridle Helen H Eisen Tim T Houlston Richard S RS
Genome research 20060601 6
We conducted a large-scale genome-wide association study in UK Caucasians to identify susceptibility alleles for lung cancer, analyzing 1529 cases and 2707 controls. To increase the likelihood of identifying disease-causing alleles, we genotyped 1476 nonsynonymous single nucleotide polymorphisms (nsSNPs) in 871 candidate cancer genes, biasing SNP selection toward those predicted to be deleterious. Statistically significant associations were identified for 64 nsSNPs, generating a genome-wide sign ...[more]
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