Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
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ABSTRACT:
SUBMITTER: Gudmundsson J
PROVIDER: S-EPMC3598012 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Publications
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer.
Gudmundsson Julius J Sulem Patrick P Rafnar Thorunn T Bergthorsson Jon T JT Manolescu Andrei A Gudbjartsson Daniel D Agnarsson Bjarni A BA Sigurdsson Asgeir A Benediktsdottir Kristrun R KR Blondal Thorarinn T Jakobsdottir Margret M Stacey Simon N SN Kostic Jelena J Kristinsson Kari T KT Birgisdottir Birgitta B Ghosh Shyamali S Magnusdottir Droplaug N DN Thorlacius Steinunn S Thorleifsson Gudmar G Zheng S Lilly SL Sun Jielin J Chang Bao-Li BL Elmore J Bradford JB Breyer Joan P JP McReynolds Kate M KM Bradley Kevin M KM Yaspan Brian L BL Wiklund Fredrik F Stattin Par P Lindström Sara S Adami Hans-Olov HO McDonnell Shannon K SK Schaid Daniel J DJ Cunningham Julie M JM Wang Liang L Cerhan James R JR St Sauver Jennifer L JL Isaacs Sara D SD Wiley Kathleen E KE Partin Alan W AW Walsh Patrick C PC Polo Sonia S Ruiz-Echarri Manuel M Navarrete Sebastian S Fuertes Fernando F Saez Berta B Godino Javier J Weijerman Philip C PC Swinkels Dorine W DW Aben Katja K KK Witjes J Alfred JA Suarez Brian K BK Helfand Brian T BT Frigge Michael L ML Kristjansson Kristleifur K Ober Carole C Jonsson Eirikur E Einarsson Gudmundur V GV Xu Jianfeng J Gronberg Henrik H Smith Jeffrey R JR Thibodeau Stephen N SN Isaacs William B WB Catalona William J WJ Mayordomo Jose I JI Kiemeney Lambertus A LA Barkardottir Rosa B RB Gulcher Jeffrey R JR Thorsteinsdottir Unnur U Kong Augustine A Stefansson Kari K
Nature genetics 20080210 3
We conducted a genome-wide SNP association study on prostate cancer on over 23,000 Icelanders, followed by a replication study including over 15,500 individuals from Europe and the United States. Two newly identified variants were shown to be associated with prostate cancer: rs5945572 on Xp11.22 and rs721048 on 2p15 (odds ratios (OR) = 1.23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than le ...[more]
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