Ontology highlight
ABSTRACT:
SUBMITTER: Crasta K
PROVIDER: S-EPMC1478175 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Crasta Karen K Huang Phillips P Morgan Garry G Winey Mark M Surana Uttam U
The EMBO journal 20060511 11
In yeast, separation of duplicated spindle pole bodies (SPBs) (centrosomes in higher eukaryotes) is an indispensable step in the assembly of mitotic spindle and is triggered by severing of the bridge that connects the sister SPBs. This process requires Cdk1 (Cdc28) activation by Tyrosine 19 dephosphorylation. We show that cells that fail to activate Cdk1 are devoid of spindles due to persistently active APCCdh1, which targets microtubule-associated proteins Cin8, Kip1 and Ase1 for degradation. T ...[more]