Ontology highlight
ABSTRACT:
SUBMITTER: Song C
PROVIDER: S-EPMC9911754 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Song Chen C Zhang Yu Y Li Yutong Y Bie Juntao J Wang Zhe Z Yang Xin X Li Haishuang H Zhu Liangyi L Zhang Tianzhuo T Chang Qing Q Luo Jianyuan J
Cell death & disease 20230209 2
During interphase, the newly duplicated pairs of centrosomes are held together by a centrosome linker, and the centrosome separation needs the disruption of this linker to induce the duplicated centrosomes separating into two distinct microtubule organization centers. The mechanism of regulating centrosome separation is however poorly understood. Here, we demonstrated that the phosphorylation of PHF5A at Y36 by the TrkA-ERK1/2-ABL1 cascade plays a critical role in regulating centrosome separatio ...[more]