Ontology highlight
ABSTRACT:
SUBMITTER: Maruyama T
PROVIDER: S-EPMC1478186 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Maruyama Takeshi T Nakamura Takahiro T Hayashi Takeshi T Yanagida Mitsuhiro M
The EMBO journal 20060511 11
The reiterated nature of histone genes has hampered genetic approach to dissect the role of histones in chromatin dynamics. We here report isolation of three temperature-sensitive (ts) Schizosaccharomyces pombe strains, containing amino-acid substitutions in the sole histone H2B gene (htb1+). The mutation sites reside in the highly conserved, non-helical residues of H2B, which are implicated in DNA-protein or protein-protein interactions in the nucleosome. In the allele of htb1-72, the substitut ...[more]