Ontology highlight
ABSTRACT:
SUBMITTER: Choi HS
PROVIDER: S-EPMC1479073 | biostudies-literature | 2006 Jul
REPOSITORIES: biostudies-literature
Biophysical journal 20060407 1
The pH-induced conformational change of influenza virus hemagglutinin (HA) has been investigated by calculating the change of electrostatic energy of the fragment of HA2 upon pH change. The average charge and electrostatic free energy are calculated as a function of pH for the fusion peptide (residues 1-20 of HA2) and the polypeptide of residues 54-77 of HA2 by using the finite difference Poisson-Boltzmann method. It is found that as pH decreases from 8 to 5, the electrostatic free energy of the ...[more]