Isolation of a human monoclonal antibody with strong neutralizing activity against diphtheria toxin.
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ABSTRACT:
SUBMITTER: Kakita M
PROVIDER: S-EPMC1479265 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Publications
Isolation of a human monoclonal antibody with strong neutralizing activity against diphtheria toxin.
Kakita Mai M Takahashi Tsuyoshi T Komiya Takako T Iba Yoshitaka Y Tsuji Takao T Kurosawa Yoshikazu Y Takahashi Motohide M
Infection and immunity 20060601 6
We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (Kd) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used as a therapeutic drug against DT in place of the traditional equine sera. ...[more]
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