Ontology highlight
ABSTRACT:
SUBMITTER: Tharakaraman K
PROVIDER: S-EPMC4568252 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Tharakaraman Kannan K Subramanian Vidya V Viswanathan Karthik K Sloan Susan S Yen Hui-Ling HL Barnard Dale L DL Leung Y H Connie YH Szretter Kristy J KJ Koch Tyree J TJ Delaney James C JC Babcock Gregory J GJ Wogan Gerald N GN Sasisekharan Ram R Shriver Zachary Z
Proceedings of the National Academy of Sciences of the United States of America 20150817 35
Emerging strains of influenza represent a significant public health threat with potential pandemic consequences. Of particular concern are the recently emerged H7N9 strains which cause pneumonia with acute respiratory distress syndrome. Estimates are that nearly 80% of hospitalized patients with H7N9 have received intensive care unit support. VIS410, a human antibody, targets a unique conserved epitope on influenza A. We evaluated the efficacy of VIS410 for neutralization of group 2 influenza st ...[more]