Ontology highlight
ABSTRACT:
SUBMITTER: Taniguchi H
PROVIDER: S-EPMC1479364 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Taniguchi Hidenori H Lowe Christopher E CE Cooper Jason D JD Smyth Deborah J DJ Bailey Rebecca R Nutland Sarah S Healy Barry C BC Lam Alex C AC Burren Oliver O Walker Neil M NM Smink Luc J LJ Wicker Linda S LS Todd John A JA
BMC genetics 20060420
<h4>Background</h4>Type 1 diabetes (T1D) is a common autoimmune disease resulting from T-cell mediated destruction of pancreatic beta cells. Decay accelerating factor (DAF, CD55), a glycosylphosphatidylinositol-anchored membrane protein, is a candidate for autoimmune disease susceptibility based on its role in restricting complement activation and evidence that DAF expression modulates the phenotype of mice models for autoimmune disease. In this study, we adopt a linkage disequilibrium (LD) mapp ...[more]