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Agents which upregulate CD55 [decay accelerating factor (DAF)] expression [Array]

ABSTRACT: (Submitter supplied) Identification of transcription factors (TFs) which upregulate human CD55 expression. CD55 was originally described as a cellular complement regulator that protects self-cells from autologous complement attack. It is now known as cellular regulator which controls many functions of cells, as examples T cell commitment to T effector cells vs Foxp3+ T regulatory cells, B2 cell Ab production, and receptor tyrosine kinase (RTK) growth factor receptor function. Overlap of the arrays identified the immunosuppressive TF Kruppel Like Factor 4 (KLF4). The current study shows that CD55 functions jointly with KLF4.

ORGANISM(S): Homo sapiens

PROVIDER: GSE255080 | GEO | 2024/02/12

REPOSITORIES: GEO

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