Ontology highlight
ABSTRACT:
SUBMITTER: Costantini DL
PROVIDER: S-EPMC1480411 | biostudies-literature | 2005 Oct
REPOSITORIES: biostudies-literature
Costantini Danny L DL Arruda Eric P EP Agarwal Pooja P Kim Kyoung-Han KH Zhu Yonghong Y Zhu Wei W Lebel Melanie M Cheng Chi Wa CW Park Chong Y CY Pierce Stephanie A SA Guerchicoff Alejandra A Pollevick Guido D GD Chan Toby Y TY Kabir M Golam MG Cheng Shuk Han SH Husain Mansoor M Antzelevitch Charles C Antzelevitch Charles C Srivastava Deepak D Gross Gil J GJ Hui Chi-chung CC Backx Peter H PH Bruneau Benoit G BG
Cell 20051001 2
Rhythmic cardiac contractions depend on the organized propagation of depolarizing and repolarizing wavefronts. Repolarization is spatially heterogeneous and depends largely on gradients of potassium currents. Gradient disruption in heart disease may underlie susceptibility to fatal arrhythmias, but it is not known how this gradient is established. We show that, in mice lacking the homeodomain transcription factor Irx5, the cardiac repolarization gradient is abolished due to increased Kv4.2 potas ...[more]