Ontology highlight
ABSTRACT:
SUBMITTER: Mori K
PROVIDER: S-EPMC5902590 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Mori Kentaro K Nakamura Harumi H Kurooka Hisanori H Miyachi Hitoshi H Tamada Kota K Sugai Manabu M Takumi Toru T Yokota Yoshifumi Y
Molecular and cellular biology 20180416 9
The cellular components and function of the gastrointestinal epithelium exhibit distinct characteristics depending on the region, e.g., stomach or intestine. How these region-specific epithelial characteristics are generated during development remains poorly understood. Here, we report on the involvement of the helix-loop-helix inhibitor Id2 in establishing the specific characteristics of the intestinal epithelium. <i>Id2</i><sup>-/-</sup> mice developed tumors in the small intestine. Histologic ...[more]