Ontology highlight
ABSTRACT:
SUBMITTER: Risueno RM
PROVIDER: S-EPMC1480457 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
Risueño Ruth M RM van Santen Hisse M HM Alarcón Balbino B
Proceedings of the National Academy of Sciences of the United States of America 20060609 25
T cell antigen receptor (TCR) triggering determines the fate of immature thymocytes. The affinity of the TCR for its endogenous peptide/MHC ligands serves as a signal for positive or negative selection through mechanisms that are still little understood. We have used a conformation-specific antibody to demonstrate that recognition of TCR ligands that lead to negative selection induces a conformational change in the TCR in situ. In contrast, this conformational change is elicited in only a small ...[more]