Ontology highlight
ABSTRACT:
SUBMITTER: Furutani K
PROVIDER: S-EPMC1482525 | biostudies-literature | 2006 May
REPOSITORIES: biostudies-literature
Furutani Kazuharu K Okubo Yohei Y Kakizawa Sho S Iino Masamitsu M
Proceedings of the National Academy of Sciences of the United States of America 20060518 22
The maintenance of synaptic functions is essential for neuronal information processing, but cellular mechanisms that maintain synapses in the adult brain are not well understood. Here, we report an activity-dependent maintenance mechanism of parallel fiber (PF)-Purkinje cell (PC) synapses in the cerebellum. When postsynaptic metabotropic glutamate receptor (mGluR) or inositol 1,4,5-trisphosphate (IP(3)) signaling was chronically inhibited in vivo, PF-PC synaptic strength decreased because of a d ...[more]