Ontology highlight
ABSTRACT:
SUBMITTER: McBride KM
PROVIDER: S-EPMC1482658 | biostudies-literature | 2006 Jun
REPOSITORIES: biostudies-literature
McBride Kevin M KM Gazumyan Anna A Woo Eileen M EM Barreto Vasco M VM Robbiani Davide F DF Chait Brian T BT Nussenzweig Michel C MC
Proceedings of the National Academy of Sciences of the United States of America 20060524 23
Activation-induced cytidine deaminase (AID) initiates Ig class switch recombination and somatic hypermutation by producing U:G mismatches in DNA. These mismatches also have the potential to induce DNA damage including double-stranded breaks and chromosome translocations; therefore, strict regulation of AID is important for maintaining genomic stability. In addition to transcriptional regulation, it has been proposed that phosphorylation can also modulate AID activity. Using a combination of MS a ...[more]